A plaster cast is a copy made in plaster of another 3-dimensional form. The original from which the cast is taken may be a sculpture, building, a face, a pregnant belly, a fossil or other remains such as fresh or fossilised footprints – particularly in palaeontology (a track of dinosaur footprints made in this way can be seen outside the Oxford University Museum of Natural History).

Sometimes a blank block of plaster itself was carved to produce mock-ups or first drafts of sculptures (usually relief sculptures) that would ultimately be sculpted in stone, by measuring exactly from the cast, for example by using a pointing machine. These are still described as plaster casts. Examples of these by John Flaxman may be found in the central rotunda of the library at University College London, and elsewhere in the University's collections. It may also describe a finished original sculpture made out of plaster, though these are rarer.